A recent study published in JAMA Psychiatry has brought new revelations regarding the withdrawal symptoms experienced by patients discontinuing antidepressants. Contrary to earlier beliefs, researchers have found that stopping these medications may not lead to severe withdrawal symptoms as previously thought. This shift in understanding is important for patients and healthcare providers alike.
A Comprehensive Study
The study involved a thorough examination of approximately 50 previous studies, with data derived from over 17,000 participants.
The majority of patients experienced only one discontinuation symptom a week after terminating their treatment. An essential takeaway is that four or more symptoms must be present for a patient to be classified as experiencing withdrawal. Among these symptoms, dizziness was the most commonly reported, while mood changes were remarkably absent.Dr. Sameer Jauhar, MBChB, BSc (Hons), FRCPsych, PhD
Past research often attracted patients already suffering from withdrawal symptoms. As a result, those surveys may have overstated the severity of discontinuation symptoms, casting a shadow over the treatment landscape.Gemma Lewis, Associate Professor from University College London
Debunking Misconceptions
The study aims to provide reassurance to both patients and healthcare providers, especially in the wake of previous studies that suggested higher symptom severity than what was found in this latest research.
This new study is extremely welcome in terms of helping to destigmatize antidepressants.Katharina Domschke, Chair of the Department of Psychiatry and Psychotherapy, University of Freiburg, Germany.
She emphasized that the term “withdrawal symptoms” is more appropriate when discussing substance dependence rather than medications.
Distinguishing Withdrawal from Relapse
A crucial aspect of this study is the distinction it makes between withdrawal and relapse.
Dr. Jauhar noted that if a patient discontinuing an antidepressant experiences a return of depressive symptoms, that signifies a relapse and should be treated accordingly. Unlike withdrawal symptoms, which emerge shortly after stopping the medication, relapse symptoms typically take longer to manifest.
Understanding Antidepressant Discontinuation Syndrome
While the findings provide a new lens to view the cessation of antidepressant treatment, it’s important to understand what antidepressant discontinuation syndrome entails. Symptoms associated with this syndrome can broadly include:
Flu-like symptoms: fatigue, headaches, muscle aches, and sweating.
Nausea: sometimes accompanied by vomiting.
Dizziness and vertigo: feelings of light-headedness.
Imbalance: difficulty maintaining one’s equilibrium.
Sensory disturbances: sensations described as “burning,” “tingling,” or “electric-like.”
Hyperarousal: increased anxiety, irritability, agitation, or even manic episodes.
These symptoms typically occur within two to four days after stopping the medication, generally resolving within one to two weeks, further emphasizing that such experiences are usually less severe than assumed.
Implications for Patient Care
The findings underscore the necessity for informed patient education regarding antidepressant discontinuation. Physicians should remain vigilant when patients consider stopping their medication, especially during sensitive times such as pregnancy. Transitioning to a medication with a longer half-life or tapering the dosage over six to eight weeks can help mitigate potential withdrawal symptoms.
Conclusion: A Step Toward Understanding
The latest research sheds light on the often-misunderstood subject of antidepressant withdrawal, signaling a need for more nuanced discussions in clinical settings. While the study presents encouraging data that suggest a less daunting experience when stopping antidepressants, the need for cautious, individualized care remains paramount. Understanding the distinctions between withdrawal and relapse will ultimately aid patients in navigating their mental health journeys, promoting informed decisions and better therapeutic outcomes.
References:
1. Perlis, Roy H. 2025. “Prevalence and Risk Factors for Discontinuation of Antidepressants in the US.” JAMA Psychiatry. Published online July 10, 2025. https://doi.org/10.1001/jamapsychiatry.2025.1362.
(Rh/Dr. Divina Johncy Rosario/MSM/SE)