
When most people think about recovery from alcohol addiction, they imagine therapy, support groups, or inpatient rehab. While these are all important tools, there’s another highly effective—and often underutilized—option: Medication-Assisted Treatment (MAT). MAT involves the use of FDA-approved medications, often alongside counseling and behavioral therapies, to support individuals as they reduce or eliminate alcohol use.
This approach is backed by science and is gaining recognition as a safe, accessible, and empowering option for those who want to break free from alcohol dependence. If you're exploring options for medication for alcohol addiction, here’s what you should know about how MAT works—and which medications may be most effective.
MAT is the use of prescription medications that help reduce cravings, minimize withdrawal symptoms, and prevent relapse. These medications don’t replace one addiction with another; instead, they help stabilize brain chemistry and give individuals the clarity and control they need to engage fully in their recovery.
It’s important to understand that MAT is most effective when combined with therapy and other forms of support—not used in isolation. This integrated approach addresses both the physical and psychological aspects of addiction.
There are several FDA-approved medications that are used to treat Alcohol Use Disorder (AUD), each targeting different aspects of the condition. Here are the most commonly prescribed:
Acamprosate helps restore the brain’s chemical balance after prolonged alcohol use. It’s especially useful for maintaining abstinence once someone has already quit drinking.
● Taken in pill form, typically three times a day
● Most effective when used after detox
● Does not prevent withdrawal symptoms or reduce cravings directly, but supports long-term sobriety
Disulfiram creates a severe physical reaction—such as nausea, vomiting, and flushing—if alcohol is consumed. This deterrent effect can be useful for individuals highly motivated to stop drinking.
● Best suited for people who have already stopped drinking
● Requires strict adherence to avoid accidental alcohol exposure
Most effective when combined with supervision and ongoing support
You can learn more about each of these medications and how they compare in this detailed breakdown from Sequoia MD’s medical team.
While MAT can be life-changing for many people, it’s not a one-size-fits-all solution. A thorough assessment by a qualified provider is essential to determine the best course of treatment. Factors like medical history, co-occurring mental health conditions, and treatment goals all play a role in choosing the right medication and support structure.
There’s no single “right” way to recover from alcohol addiction—but there are more options than ever before. For some, medication provides the extra support needed to stay on track, reduce cravings, and avoid relapse. For others, it’s a bridge toward long-term sobriety when other methods haven’t worked.
Sequoia MD offers personalized, physician-led medication for alcohol addiction that’s grounded in compassion and clinical expertise. If you're curious about MAT or want to explore whether it's right for you, their team is here to help you find clarity and confidence in your next step.