An ischemic stroke is caused by a blockage of blood flow to the brain and is the most common type of stroke.
To evaluate the genetic relationship between smoking and stroke recovery, researchers analyzed the results of a meta-analysis of 12 studies from the United States, Europe, and Australia, examining genetics and stroke recovery. The studies included 6,021 people of European genetic ancestry who had an ischemic stroke. Recovery levels were measured three months after the stroke.
Recovery was defined in two ways—good and poor—with good meaning people had fully recovered or had slight disability but required no help from others, and poor meaning they had moderate disability requiring assistance, severe disability, or had died. A total of 3,741 people had good stroke recovery and 2,280 had poor recovery.
Researchers used a study design called Mendelian randomization to determine if there was a cause and effect between 373 genetic variations called single nucleotide polymorphisms (SNPs) known to be linked to an increased risk of smoking and poor recovery from stroke. SNPs are common and can act as biological markers, helping locate genes that are associated with disease.
After adjusting for age, sex, and stroke severity, researchers found that people who were genetically predisposed to smoking had a 48% greater risk of worse stroke recovery than those who were not genetically predisposed. The results stayed the same when researchers adjusted further for genetically predicted alcohol consumption.
A limitation of the study was that participants were of European ancestry, so larger studies are needed in other ethnic populations. (NR/Newswise)
