From ‘Nose-to-Nose with Death’ to Hope: James Van Der Beek’s Fight Against Colon Cancer and the Power of Early Detection

Actor James Van Der Beek reveals how he came “nose-to-nose with death” after a hidden symptom led to a stage 3 colon cancer diagnosis. Learn how the Shield blood test by Guardant Health helps detect colorectal cancer early, and why screening at 45 could save your life.

James Van Der Beek’s life took a drastic turn after noticing a subtle change in his bowel habits. Thinking it was due to coffee, he ignored the symptom until a routine colonoscopy confirmed stage 3 colorectal cancer.

“I was doing everything: biohacking, cold plunges, Pilates,” he told. “Then the diagnosis hit, and I was nose-to-nose with death.” Despite the devastation, the actor found hope in a profound realization: “I’m still worthy of love.”

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the U.S., often developing with few or no symptoms in the early stages. Subtle signs like changes in stool are frequently overlooked until the disease is advanced.

Recognizing the urgent need for accessible screening options, Guardant Health, a leading precision oncology company, developed Shield - an FDA-approved, blood-based test designed to detect colorectal cancer in average-risk adults aged 45 and up.

Guardant Health specializes in transforming cancer care through cutting-edge blood tests and data-driven insights, enabling earlier detection, improved treatment decisions, and better outcomes for patients.

With Shield, adults can undergo a simple blood draw, a breakthrough alternative to traditional colonoscopy, which many avoid due to discomfort or time constraints.

Due to a rise in early-onset colorectal cancer, major health organizations have lowered the recommended screening age to 45—even for those with no symptoms or family history.

“If you're 45 or older, talk to your doctor. Get screened,” Van Der Beek urges. “Don’t wait for symptoms. The earlier you detect it, the better your chances over 90% survival in early stages.”

This updated guidance reflects a broader effort to prevent late-stage diagnoses by catching cancer earlier, when treatment is most effective.

Beyond the physical battle, Van Der Beek faced emotional and existential reckoning. With his identity stripped down during treatment, he found healing through vulnerability and spiritual acceptance.

Today, he channels that truth into purpose-driven advocacy, helping others understand the risks, recognize symptoms, and access better screening options.

James Van Der Beek’s message is clear: don’t wait. Get screened. You’re worth saving.

Whether through traditional colonoscopy or the innovative Shield blood test by Guardant Health, early detection can save your life.

(Rh/Eth/VK/MSM/SE)