How a Standard WHO ORS Packet Triggered Severe Hyperkalemia in a Chronic Kidney Disease Patient

A physician’s social media post draws attention to the potential risks of potassium-containing oral rehydration solutions in patients with chronic kidney disease.
Cross section of 3 kidneys with the last one with some stones.
According to the Centers for Disease Control and Prevention (CDC), chronic kidney disease is a condition in which the kidneys are damaged and cannot filter blood as effectively as they should.Brgfx- Freepik
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A recent social media (X) post by physician Dr. Priyam Bordoloi, MBBS, MD Internal Medicine final year resident described a case in which a patient with chronic kidney disease (CKD) developed severe hyperkalemia (High potassium) after consuming World Health Organization (WHO) oral rehydration solution (ORS) for mild diarrhea.

According to the post, the patient had a history of recurrent elevated potassium levels, with a previous serum potassium of 5.3 mEq/L. After being advised to consume WHO ORS for hydration by a quack, the patient presented to the emergency department with profound muscle weakness, palpitations and perioral numbness.

Laboratory results revealed a potassium level of 6.4 mEq/L, a value considered medically significant and potentially life-threatening.

Hyperkalemia refers to elevated potassium levels in the blood. Normal potassium levels typically range from 3.5 to 5.0 mEq/L.

In the post, Dr. Bordoloi reminds everyone why it is important to get medical advice only from qualified medical professionals, since even a simple ORS drink might put you in an emergency room.

A screengrab of the 'X' post by Dr. Priyam Bordoloi.
CKD is typically defined by abnormalities in kidney structure or function lasting more than three months.Dr. Priyam Bordoloi @DocPriyamMD - X

What Is Chronic Kidney Disease (CKD)?

According to the Centers for Disease Control and Prevention (CDC)1, chronic kidney disease is a condition in which the kidneys are damaged and cannot filter blood as effectively as they should.

Healthy kidneys perform several essential functions:

  • Remove waste and excess fluids

  • Maintain electrolyte balance (including potassium)

  • Regulate blood pressure

  • Support red blood cell production

CKD is typically defined by abnormalities in kidney structure or function lasting more than three months.

Pain and stomache old senior asian grandfather in patient uniform suffer from body problem health ideas concept
In patients with healthy kidneys, excess potassium is excreted through urine.Lifestylememory - Freepik

Causes of Chronic Kidney Disease

The CDC identifies the most common causes of CKD as:

  • Diabetes

  • High blood pressure (hypertension)

  • Heart disease

  • Family history of kidney disease

Other contributing factors may include autoimmune conditions, infections, and long-term use of certain medications.

Symptoms of CKD

In early stages, CKD may not cause noticeable symptoms. As the disease progresses, patients may experience:

  • Fatigue

  • Swelling in feet or ankles

  • Changes in urination patterns

  • Muscle cramps

  • Nausea

  • Shortness of breath

Electrolyte imbalances, particularly abnormal potassium levels, can also occur.

High Potassium levels result in muscle weakness, abnormal heart rhythms and even cardiac arrest.

WHO Oral Rehydration Solution and Potassium Content

WHO ORS is designed to treat dehydration caused by diarrhea. It contains a balanced mixture of:

  • Sodium

  • Glucose

  • Chloride

  • Potassium (approximately 20 mEq/L in standard formulation)

  • Citrate

In healthy individuals, ORS is widely regarded as safe and lifesaving, particularly in cases of infectious diarrhea.

However, in patients with advanced kidney disease, additional potassium intake may pose a risk if the kidneys cannot eliminate it effectively.

Reference

  1. Centers for Disease Control and Prevention. “Preventing Chronic Kidney Disease” CDC. Accessed February 17th 2026. https://www.cdc.gov/kidney-disease/prevention/index.html

MSM

Cross section of 3 kidneys with the last one with some stones.
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