A study revealed a connection between depression and cardiovascular disease (CVD). Researchers identified a specific set of genes, known as a 'gene module,' that are affected by both disorders, revealing new insights into their underlying mechanisms. This study has the potential to modify the method by which depression and CVD are diagnosed, treated, and prevented.
The link between depression and cardiovascular disease has puzzled scientists and healthcare practitioners for decades. Despite increasing confirmation of their relationship, their exact connection remained unknown. A team of researchers has made an important discovery, revealing a similar genetic route that contributes to the development of both illnesses.
Researchers used data from the Young Finns project, one of the largest investigations of cardiovascular risk factors, to assess gene expression profiles in approximately 900 individuals' blood. They discovered a particular gene module of 256 functionally linked genes that are expressed similarly in people with depression and those at risk of CVD.
This genetic module, having various expression patterns, serves as a biomarker for both depression and cardiovascular disease. Its discovery opens up new diagnostic tools and therapeutic targets, potentially leading to more effective treatments for these chronic diseases.
The gene module associated with both depression and CVD includes genes involved in inflammatory processes, which are implicated in the pathogenesis of both conditions.
Individuals with depression and those at risk of CVD exhibit altered expression levels of genes within this module, indicating a shared biological pathway underlying both diseases.
Lifestyle factors commonly associated with depression, such as poor diet and lack of exercise, may contribute to the link between depression and cardiovascular disease. However, the study suggests that the shared genetic pathway is a crucial factor in their relationship.
Dr. Binisha H. Mishra, the lead author of the study, emphasizes the significance of these findings: "We looked at gene expression profiles in the blood of people with depression and CVD and found 256 genes in a single gene module whose expression at levels higher or lower than average puts people at greater risk of both diseases."
This study paves the way for novel therapeutic interventions targeting shared pathways by identifying the genetic basis of the connection between depression and cardiovascular disease. Ultimately, these insights could lead to the development of dual-purpose preventative strategies for both depression and CVD, improving public health outcomes worldwide.
The research highlights the intricate relationship between depression and cardiovascular disease, providing a deeper understanding of their shared biological mechanisms. This discovery has the potential to develop customized treatments and improve patient care for people living with these common and painful diseases.
(Input from various media sources)
(Rehash/ Susmita Bhandary/MSM)
