Bryan Johnson’s Latest Anti-Aging Experiment: Plasma Replacement

After his first plasma experiment failed, the tech millionaire returns with a new one
Johnson shared the experiment on social media with the goal to understand about how ketamine affects brain function.
Bryan Johnson replaced all of his plasma with albumin protein in the latest experiment.(Image from Instagram/Bryan Johnson)
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Bryan Johnson, a US-based millionaire known for his unusual anti-aging experiments, is making headlines once again. This time, he underwent a complete plasma exchange, replacing it with albumin—a protein found in the human body. He referred to it as “V2 or Version 2” of the Blood Boy experiment.

Who is Bryan Johnson?

Bryan Johnson is the founder of companies like Braintree and Kernel. He is best known for Blueprint, his intense anti-aging protocol where he tracks hundreds of health markers and follows a strict diet and exercise routine. He spends more than 2 million dollars every year to try and reverse the effects of natural aging and keeps experimenting with different theories to find the exact workable solution.

Johnson explains, “Everything I do is an attempt at discovering what slows down my speed of aging and reverses my aging damage. We follow the science and data, no matter how outlandish the therapies may seem.”

Blood Boy – His First Experiment

In 2023, he made headlines when he took part in a plasma swap experiment, where his 17-year-old son donated plasma to him, and he called it “Blood Boy.” The experiment was based on the idea that young plasma might slow aging. After six months, he termed this trial a failure after seeing no significant results.

What’s New in V2?

In his latest experiment, Johnson replaced all of his plasma with a solution containing 5% albumin and IVIG (Intravenous Immunoglobulins), a technique based on the plasma exchange therapy used in treating certain medical conditions. Experts caution that such plasma replacement procedures are not yet validated for anti-aging and could pose risks if done outside clinical necessity.

Johnson said, “We replaced all the plasma from my body, and my doctor said it's the cleanest she has ever seen.”

According to him, they are following the theory where all the toxic substances are replaced with fresh ones and the body rebuilds the plasma. In his video, he explained, “Your body has a natural ability to remove waste products, but sometimes it can’t deal with the load of our modern world or certain kinds of toxins.”

But to understand why this matters, first let’s see what plasma is.

Plasma is the liquid part of blood that helps carry cells, hormones, and nutrients around the body. It plays a major role in keeping the body healthy by maintaining blood pressure, carrying immune cells to the site of infection, transporting proteins that repair tissue damage, and removing waste products.

A hand with gloves holding a syringe connected with a tube, preparing for a medical procedure.
Without plasma, our body would not be able to support blood clotting and immune system responses.(Representational Image: Freepik)

What happens when all the plasma is removed?

According to Johnson, nothing really happened after the process. He mentioned, “I did the entire thing—I felt the same, went to bed, slept the same.” For him, it was pretty inconsequential, but he acknowledged that those who are dealing with health challenges can feel a significant boost of energy and alertness.

What comes next?

While the immediate effects of Johnson’s plasma replacement experiment appear minimal, the real insights will come from tracking long-term changes in his biomarkers. Whether this radical approach offers a breakthrough in longevity science or just another data point in his ongoing quest, only time will tell. For now, Johnson continues to push the boundaries of what’s possible in the anti-aging space, inviting both curiosity and skepticism from the scientific community.

(Input from various sources)

(Rehash/Pooja Bansal/MSM)

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