Altering Key Ion Channel Protects Against Pancreatitis-Associated Acute Lung Injury

Mice without Orai1 lose protection against localized pancreatic injury during acute pancreatitis
A group of Chinese researchers conducted a recent mouse study to determine the role of Orai1, a membrane calcium-selective ion channel protein, in pancreatitis-associated acute lung injury (Representational image : Wikimedia commons)
A group of Chinese researchers conducted a recent mouse study to determine the role of Orai1, a membrane calcium-selective ion channel protein, in pancreatitis-associated acute lung injury (Representational image : Wikimedia commons)

A group of Chinese researchers conducted a recent mouse study to determine the role of Orai1, a membrane calcium-selective ion channel protein, in pancreatitis-associated acute lung injury. Their findings, published in the journal Function, revealed that Orai1 in pancreatic parenchymal cells (cells responsible for detoxification in the liver and filtering toxins in the kidneys) mediates pancreatic acute lung injury in acute pancreatitis. Mice without Orai1 lose protection against localized pancreatic injury during acute pancreatitis. However, the protein does protect against pancreatitis-associated acute lung injury by blocking white blood cell-intrinsic functions.

This study provided invaluable preclinical evidence for the feasibility of targeting ORAI1 in two distinct cellular sources (Representational image : Wikimedia commons)
This study provided invaluable preclinical evidence for the feasibility of targeting ORAI1 in two distinct cellular sources (Representational image : Wikimedia commons)

“This study provided invaluable preclinical evidence for the feasibility of targeting ORAI1 in two distinct cellular sources,” said Li Wen, MD, PhD, a professor and principal investigator at Peking Union Medical College Hospital in China, and lead author of the study.

A group of Chinese researchers conducted a recent mouse study to determine the role of Orai1, a membrane calcium-selective ion channel protein, in pancreatitis-associated acute lung injury (Representational image : Wikimedia commons)
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This further emphasizes that systemic administration of Orai1 inhibitors is a promising therapeutic strategy as an early treatment of acute pancreatitis. We believe this will also help accelerate the clinical development of Orai1 inhibitors.
Li Wen, MD, PhD,Professor at Peking Union Medical College Hospital in China

Read the full article, “Neutrophil-specific ORAI1 calcium channel inhibition reduces pancreatitis-associated acute lung injury,” published ahead of print in Function. Contact APS Media Relations or call 301.634.7314 to schedule an interview with a member of the research team. (VP/Newswise)

A group of Chinese researchers conducted a recent mouse study to determine the role of Orai1, a membrane calcium-selective ion channel protein, in pancreatitis-associated acute lung injury (Representational image : Wikimedia commons)
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