New research led by the Seaver Autism Center for Research and Treatment at Mount Sinai has illuminated genetic differences among children with a rare neurodevelopmental condition and could point the way toward a precision medicine approach to caring for these children.
The study is the first of its kind to directly assess differences between individuals with mutations in the CHAMP1 gene and those with deletions of the gene. The analysis was published in Human Genetics on July 17.
CHAMP1 disorder is a genetic, neurodevelopmental condition associated with intellectual disability, medical comorbidities (e.g., seizures, gastrointestinal problems), and dysmorphic features. The disorder is caused by mutations or deletions of the CHAMP1 gene.
Researchers from the Seaver Autism Center performed clinical evaluations of two groups of subjects: 16 individuals with CHAMP1 coding mutations (spelling changes in the gene), and eight individuals with deletions of CHAMP1.
The group with CHAMP1 gene mutations revealed significantly lower adaptive functioning skills than those with deletions across all areas assessed, including communication, daily living skills, socialization, and motor skills. Those in the mutation group also had more severe developmental delays and were more likely to have low muscle tone and gastrointestinal abnormalities.
Researchers hypothesize that the variation in symptoms is likely attributable to differences in the mechanisms behind the deletions and mutations of the CHAMP1 gene. Deletions act through CHAMP1 haploinsufficiency, which occurs when the remaining functioning copy of the CHAMP1 gene is not adequate to preserve normal function alone. Mutations may be acting through dominant negative or gain-of-function mechanisms, which actively interfere with the normal gene function and lead to more severe clinical symptoms.
The study results illustrate the importance of understanding the mechanisms of mutations and deletions prior to treatment development for CHAMP1 and other disorders, like autism, that have broad diagnosis with differing genetic causes.
About the Seaver Autism Center for Research and Treatment
The Seaver Autism Center is one of the most recognized institutions of its kind in the world because of its ability to translate breakthroughs in the lab to clinical trials that bring cutting-edge treatment to individuals affected by autism spectrum disorder (ASD) and associated neurodevelopmental disorders.
We offer compassionate care, including assessment and behavioural health services, to children and families, as well as educational and community outreach programs. Founded in 1993 and located at the Icahn School of Medicine at Mount Sinai, families come from around the world to seek our services and the expert counsel of our team of scientists, researchers and clinicians.
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