Research is shedding light and potentially expanding options for patients living with Medulloblastoma, an aggressive childhood cancer.
Medulloblastoma is a cancer impacting both very young and school aged children.
When children get this type of brain tumor, they experience the process of the tumor blocking flow of fluid around the brain.
This can cause severe headaches, vomiting, sleepiness, fussiness, and difficulty walking and coordinating movements.
Treatment is intense, involving high dose chemotherapy, surgery, and sometimes radiation or stem cell transplants.
During these months long treatments, children may lose hair, lose weight, be unable to eat and experience lots of upset stomachs.
Medulloblastoma is also a complex disease with many different genetic causes, making a one-size-fits-all approach to treatment impossible.
Prensner’s group paired up with the team of Sebastiaan van Heesch, Ph.D., research group leader at the Princess Máxima Center for pediatric oncology in the Netherlands, to examine several groups of patients, some of which experienced the most aggressive form of the cancer and had the poorest outcomes.
Many of those patients had biological and genetic factors that exacerbated their cancers, including the cancer gene MYC.
Prensner’s team and their collaborators took a new hypothesis on how MYC might be functioning and how that might be implicated in cancer.
“The twist that we put on it is to ask the question, what if this MYC is doing important functions outside of what we know to be genes in these cancer cells?” Prensner said.
With further understanding of MYC and other genetic, biological, and cellular factors, providers can then learn how to intervene with these cancers.
Furthermore, the research could support development of therapeutics that could target the molecular process allowing cancer cells to grow.
This study may be newer, but Prensner’s interest in medulloblastoma is not.
His experience began early when he was a medical student; he was moved by the patients he met who were living with the tumor.
“I've never forgotten, not just the patients, but the families. That's why it's been so important to me to try to use the interests and training that I have in the scientific fields to think about how we can really unlock new areas of understanding about this disease to get these patients better choices,” he said.
“Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma,” (SG/Newswise)