Patients with the genetic disorder hemophilia A receive factor VIII protein replacement treatments to replenish this clotting protein in their blood, thus preventing dangerous bleeding. In a recent study published in Blood, researchers from Indiana University School of Medicine shed new light on the underlying causes of immune response to factor VIII, providing valuable insights that could lead to more effective and safer hemophilia A treatments in the future.
The research team led by Radek Kaczmarek, PhD, assistant research professor of pediatrics and Roland Herzog, PhD, professor of pediatrics and director of the Gene and Cell Therapy Program at the Herman B Wells Center for Pediatric Research studied the connections between factor VIII, immune cells and the spleen to uncover what leads to the negative response of inhibitor formation.
The study also identified the immune response to factor VIII was made stronger by stimulating an innate immune sensor called Toll-like receptor 9. Furthermore, the research team noted that factor VIII not only impacts its own immune response but may also enhance the immune system's reactivity to other antigens, indicating intrinsic immunostimulatory properties.
“The most surprising finding in our study was that antigens may take different routes to reach T cell zones in the spleen,” said Herzog. “These differences in trafficking offer a new perspective on why antigens differ in immunogenicity.”
Overall, these findings collectively represent a significant step forward in unraveling the mysteries of hemophilia A complicated with factor VIII inhibitor and may help develop more tailored and efficient treatment approaches. (VKR/Newswise)